The Stop TB USA Board is comprised of up to 12 members from the general Partnership membership. Ex-officio members of the Board include: a representative of the American Thoracic Society (ATS), the Director of the Division of Tuberculosis Elimination, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, and the current President of the National Tuberculosis Controllers Association.

The Coordinating Board is responsible for overall policy and direction of the Partnership;  approval of the Stop TB USA Annual Work; management oversight of and approval of the work of the Executive Director/Secretariat (ATS);  review the progress of the implementation of the Stop TB Partnership and maintenance of a program of frequent, high quality information exchange, including reports of its meetings, with all Partners and the public at large; and adoption of an appropriate financial policy in collaboration with the Secretariat/ATS to underpin financial decisions and accounting for any resources entrusted to the Stop TB Secretariat;

The Board conducts monthly conference calls and meets face-to-face at least bi-annually in collaboration with a partner organization with an effort to build public awareness of TB.